Antibody dependent enhancement (ADE) is implicated in the immunopathogenesis of –

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Antibody dependent enhancement (ADE) is implicated in the immunopathogenesis of –

[A]. Staphylococcal toxic shock syndrome

[B]. SSPE

[C]. Dengue hemorrhagic fever

[D]. Waterhouse-friderichsen syndrome



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[C]. Dengue hemorrhagic fever

Explanation :-

ANTIBODY-DEPENDENT ENHANCED (ADE) IMMUNITY

  • After a person is infected with dengue, they develop an immune response to that dengue subtype.
  • The immune response produced specific antibodies to that subtype specific surface proteins that prevents the virus from binding to macrophage cells (the target cell that dengue viruses infect) and gaining entry.
  • However, if another subtype of dengue virus infects the individual, the virus will activate the immune system to attack it as if it was the first subtype.
  • The immune system is tricked because the four subtypes have very similar surface antigens.
  • The antibodies bind to the surface proteins but do not inactivate the virus.
  • The immune response attracts numerous macrophages, which the virus proceeds to infect because it has not been inactivated.
  • Its because of this phenomenon body releases cytokines that cause the endothelial tissue to become permeable which results in Dengue Haemorrhagic Fever (DHF) and fluid loss from the blood vessels.
  • Also remember that, Ebola virus also exhibits ADE.

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